The default ADC report template contains a DAR calculation which is suitable for intact ADCs.
It's relatively straight forward to adapt this report template to calculate DAR for reduced molecules.
To do this, open the default report.
Note: If the default ADC report is not already loaded it can be done so by selecting:
File/Presets/Report presets/Intact_ADC_Report_withPlots.rptc
Once the report is open, the script that is used to calculate the DAR fraction can be opened and edited.
To open the script select Edit/Edit pre pivot dynamic columns...
The pre pivot dynamic function script used to calculate DAR is the [DARFractionSubunit]. To edit the script, click the pencil icon:
Scroll to the end of the script and add the 2* to the following position:
Click OK then Finish and reload.
The DAR fraction will now be multiplied by 2 to reflect the value on the reduced molecule.
If you have any issues editing the script contact support@proteinmetrics.com